Deep Learning Models for Early Detection of Ovarian Cancer: A Systematic Review of Ultrasound-Based Diagnostic Tools
DOI:
https://doi.org/10.70112/ajeat-2024.13.2.4246Keywords:
Ovarian Cancer (OC), Deep Learning, Early Detection, Ultrasound Imaging, Artificial Intelligence (AI)Abstract
Ovarian Cancer (OC) remains one of the most lethal gynecological malignancies, with a global 5-year survival rate of only 45%. This project aimed to assess the potential of deep learning-based diagnostic tools in improving early detection of ovarian cancer, particularly through ultrasound imaging. The primary research problem lies in the challenge of accurately diagnosing OC at an early stage, as traditional imaging techniques often rely on subjective interpretations, leading to inconsistent results. To address this issue, a systematic review was conducted following PRISMA guidelines, evaluating studies published between January 2018 and May 2023 in the Scopus and PubMed databases. These studies employed deep learning or artificial intelligence models for the diagnosis, prognosis, or identification of OC from ultrasound images. Of the 101 studies screened, 9 met the inclusion criteria. The included studies reported diagnostic accuracies of deep learning models ranging from 75% to 100%, with sensitivities between 85% and 99%. The conclusions indicate that deep learning models significantly enhance the diagnostic accuracy of ovarian cancer, offering a promising non-invasive tool for early detection. This research underscores the importance of integrating AI technologies into clinical practice to improve survival outcomes for OC patients.
References
Y. Gao et al., “Deep learning-enabled pelvic ultrasound images foraccurate diagnosis of ovarian cancer in China: A retrospective, multicentre, diagnostic study,” EClinical Medicine, vol. 53, p. 101662, Mar. 2022, doi: 10.1016/S2589-7500(21)00278-8.
P. G. Rose, M. S. Piver, Y. Tsukada, and T. S. Lau, “Metastatic patterns in histologic variants of ovarian cancer: An autopsy study,” Cancer, vol. 64, no. 7, pp. 1508-1513, Oct. 1989, doi: 10.1002/1097-0142(19891001)64:7<1508::aid-cncr2820640725>3.0.co;2-v.
P. M. Webb and S. J. Jordan, “Epidemiology of epithelial ovarian cancer,” Best Pract. Res. Clin. Obstet. Gynaecol., vol. 41, pp. 3-14, 2017, doi: 10.1016/j.bpobgyn.2016.08.006.
F. Arezzo et al., “A machine learning approach applied togynecological ultrasound to predict progression-free survival inovarian cancer patients,” Arch. Gynecol. Obstet., vol. 306, no. 6, pp. 2143-2154, Dec. 2022, doi: 10.1007/s00404-022-06578-1.
A. Barua et al., “Histopathology of ovarian tumors in laying hens: Apreclinical model of human ovarian cancer,” Int. J. Gynecol. Cancer, vol. 19, no. 4, pp. 531-539, May 2009, doi: 10.1111/IGC.0b013e3181a41613.
A. Urushibara et al., “The efficacy of deep learning models in the diagnosis of endometrial cancer using MRI: A comparison with radiologists,” BMC Med. Imaging, vol. 22, no. 1, p. 80, Apr. 2022, doi: 10.1186/s12880-022-00808-3.
Y. Jung et al., “Ovarian tumor diagnosis using deep convolutional neural networks and a denoising convolutional autoencoder,” Sci. Rep.,vol. 12, no. 1, p. 17024, Oct. 2022, doi: 10.1038/s41598-022-20653-2.
B. Wiestler and B. Menze, “Deep learning for medical image analysis: A brief introduction,” Neuro-Oncology Adv., vol. 2, pp. IV35-IV41, 2020, doi: 10.1093/noajnl/vdaa092.
R. Almajalid, J. Shan, Y. Du, and M. Zhang, “Development of a deep-learning-based method for breast ultrasound image segmentation,” in2018 17th IEEE International Conference on Machine Learning and Applications (ICMLA), IEEE, 2018, pp. 1103-1108.
A. Mikołajczyk and M. Grochowski, “Data augmentation forimproving deep learning in image classification problem,” in 2018 International Interdisciplinary PhD Workshop (IIPhDW), IEEE, 2018, pp. 117-122.
Z. Cao, L. Duan, G. Yang, T. Yue, and Q. Chen, “An experimentalstudy on breast lesion detection and classification from ultrasound images using deep learning architectures,” BMC Med. Imaging, vol. 19, pp. 1-9, 2019.
S.-T. Hsu et al., “Automatic ovarian tumors recognition system based on ensemble convolutional neural network with ultrasound imaging,” BMC Med. Inform. Decis. Mak., vol. 22, no. 1, p. 298, Nov. 2022,doi: 10.1186/s12911-022-02047-6.
F. Christiansen et al., “Ultrasound image analysis using deep neuralnetworks for discriminating between benign and malignant ovarian tumors: Comparison with expert subjective assessment,” Ultrasound Obstet. Gynecol., vol. 57, no. 1, pp. 155-163, Jan. 2021, doi: 10.1002/ uog.23530.
V. Chiappa et al., “A decision support system based on radiomics and machine learning to predict the risk of malignancy of ovarian masses from transvaginal ultrasonography and serum CA-125,” Eur. Radiol. Exp., vol. 5, no. 1, p. 28, Jul. 2021, doi: 10.1186/s41747-021-00226-0.
H. Wang et al., “Application of deep convolutional neural networks for discriminating benign, borderline, and malignant serous ovarian tumors from ultrasound images,” Front. Oncol., vol. 11, p. 770683, 2021, doi: 10.3389/fonc.2021.770683.
J. Martínez-Más et al., “Evaluation of machine learning methods with Fourier Transform features for classifying ovarian tumors based on ultrasound images,” PLoS One, vol. 14, no. 7, pp. 1-14, 2019, doi: 10.1371/journal.pone.0219388.
U. R. Acharya et al., “GyneScan: An improved online paradigm for screening of ovarian cancer via tissue characterization,” Technol. Cancer Res. Treat., vol. 13, no. 6, pp. 529-539, Dec. 2014, doi: 10.7785/tcrtexpress.2013.600273.
H.-L. L. Xu et al., “Artificial intelligence performance in image-based ovarian cancer identification: A systematic review and meta-analysis,” EClinical Medicine, vol. 53, p. 101662, Nov. 2022, doi: 10.1016/j.eclinm.2022.101662.
E. E. Onuiri and O. J. Adeniyi, “Evaluating machine learning models for predicting prostate cancer progression using lifestyle factors: A systematic review and meta-analysis,” Asian Journal of Engineering and Applied Technology, vol. 13, no. 1, pp. 44-56, 2024, doi: 10.70112/ajeat-2024.13.1.4241.
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